Publications Updated 21.11.2022

1. Bakkalci1 D, Zaki A, Zubir A, Khurram SA, Pope J, Heikinheimo K, Fedele S, Cheema U. Modelling stromal compartments to recapitulate the ameloblastoma tumour microenvironment. Matrix Biology Plus, online.
   IF 4.93 All Impact Factors 2021/2022 [article]
2. Pape J, Bakkalci D, Hosni RA, Simpson BS, Heikinheimo K, Fedele S, Cheema U. RANKL neutralization prevents osteoclast activation in a human in vitro ameloblastoma-bone model. Journal of Tissue Engineering, in press.
   IF 7.813
3. Fujii S, Ishibashi T, Kokura M, Fujimoto T, Matsumoto S, Shidara S, Kurppa KJ, Pape J, Caton J, Morgan PR, Heikinheimo K, Kikuchi A, Jimi E and Kiyoshima T. RAF1–MEK/ERK pathway-dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation. J Pathol. 2022;235:119-133. Published online 16 November 2021
   IF 7.996 [abstract]
4. Peralta S, Duhamel GE, Katt WP, Heikinheimo K, Miller AD, Ahmed F, McCleary-Wheeler AL, Grenier JK. Comparative transcriptional profiling of canine acanthomatous ameloblastoma and homology with human ameloblastoma. Scientific reports 2021;11:17792.
   IF 4.379 [article]
5. Peralta S, McCleary-Wheeler AL, Duhamel GE, Heikinheimo K, Grenier JK. Ultra-frequent HRAS p.Q61R somatic mutation in canine acanthomatous ameloblastoma reveals pathogenic similarities with human ameloblastoma. Vet Comp Oncol. 2019 June 17(2):1-7.
   IF 2.613 [abstract]
6. Heikinheimo K, Huhtala JM, Thiel A, Kurppa KJ, Heikinheimo H, Kovac M, Kragelund C, Warfvinge G, Dawson H, Elenius K, Ristimäki A, Baumhoer D, Morgan PR. The Mutational Profile of Unicystic Ameloblastoma. J Dent Res. 2019 Jan 98(1):54-60.
   IF 6.116 [abstract]
7. Lääveri M, Heikinheimo K, Baumhoer D, Slootweg P, Happonen RP. Periosteal fasciitis in a 7-year old girl – a diagnostic dilemma. Int J Oral Max Surg. 2017 Jul 46(7):863-885.
   IF 2.789 [abstract]
8. Puolakkainen T, Hongqian Ma H, Kainulainen H, Pasternack A, Rantalainen T, Ritvos O, Heikinheimo K, Hulmi J, Kiviranta R. Treatment with soluble activin type IIB-receptor improves bone mass and strength in a mouse model of Duchenne muscular dystrophy. BMC Musculoskel Disord. 2017 Jan 19;18(1):20.
   IF 2.362 [abstract]
9. Vered M, Muller S, Heikinheimo K. Ameloblastoma, in El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ Eds: World Health Organization Classification of Head and Neck Tumours, 4th Edition. IARC, Lyon 2017;215–218.
10. Radlanski RJ, Renz H, Zimmermann CA, Schuster FP, Voigt A, Heikinheimo K. Chondral ossification centers next to dental primordia in the human mandible: A study of the prenatal development ranging between 68 to 270mm CRL. Ann Anat. 2016 Aug 4;208:49-57.
    IF 2.698 [abstract]
11. Heikinheimo K, Kurppa KJ, Elenius K. Novel targets for the treatment of ameloblastoma. J Dent Res. 2015 Feb;94(2):237-40.
    IF 6.116 [full article]
12. Heikinheimo K, Kurppa KJ, Laiho A, Peltonen P, Berdal A, Bouattour A, Ruhin B, Catón J, Thesleff I, Leivo I, Morgan PR. Early dental epithelial transcription factors distinguish ameloblastoma from keratocystic odontogenic tumor. J Dent Res. 2015 Jan;94(1):101-11.
    IF 6.116 [abstract]
13. Van Dongen S, Galis F, Ten Broek C, Heikinheimo K, Wijnaendts LC, Delen S, Bots J. When right differs from left: Human limb directional asymmetry emerges during very early development. Laterality. 2014;19(5):591-601.
    IF 1.826 [abstract]
14. Van Dongen S, Galis F, Ten Broek C, Heikinheimo K, Wijnaendts LC, Delen S, Bots J. No sexual dimorphism in human prenatal metacarpal ratios. Early Hum Dev. 2014 Mar;90(3):157-60.
    IF 2.079 [abstract]
15. Kurppa KJ, Catón J, Morgan PR, Ristimäki A, Ruhin B, Kellokoski J, Elenius K, Heikinheimo K. High frequency of BRAF V600E mutations in ameloblastoma. J Pathol. 2014 Apr;232(5):492-8.
    IF 7.996 [abstract]
16. Juuri E, Isaksson S, Jussila M, Heikinheimo K, Thesleff I. Expression of stem cell marker Sox2 in ameloblastoma and dental epithelium. Eur J Oral Sci. 2013 Dec;121(6):509-16.
    IF 1.556 [abstract]
17. Radlanski R, Heikinheimo K, Gruda A. Kephalometrische Untersuchungen an menschlichen fetalen Kopfpräparaten. J Orofac Orthop 2013; 74:332–348;
    IF 1.938 [abstract]
18. Juuri E, Jussila M, Seidel K, Holmes S, Wu P, Richman J, Heikinheimo K, Chuong CM, Arnold K, Hochedlinger K, Klein O, Michon F, Thesleff I. Sox2 marks epithelial competence to generate teeth in mammals and reptiles. Development. 2013 Apr;140(7):1424–32.
    IF 6.868 [abstract]
19. Mohazab L, Koivisto L, Jiang G, Kytömäki L, Haapasalo M, Owen GR, Wiebe C, Xie Y, Heikinheimo K, Yoshida T, Smith CE, Larjava JH. Critical role for alpha-v-beta-6 integrin in enamel biomineralization. J Cell Sci. 2013 Feb 1;126(Pt 3):732–44.
    IF 5.285 [abstract]
20. Jee KJ, Persson M, Heikinheimo K, Passador-Santos F, Aro K, Knuutila S, Odell E W, Mäkitie A, Sundelin K, Stenman G, Leivo I. Genomic profiles and CRTC1-MAML2 fusion distinguish different subtypes of mucoepidermoid carcinoma. Modern Pathol. Feb;26(2):213-22, 2013.
    IF 7.842 [abstract]
21. Bots J, Wijnaendts LCD, Delen S, Van Dongen S, Heikinheimo K and Galis F. Analysis of cervical ribs in a series of human fetuses. J Anat. Sep;219(3):403–9. 2011.
    IF 2.610 [abstract]
22. Mahoney MG, Sadowski S, Brennan D, Pikander P, Saukko P, Wahl J, Aho, Heikinheimo K, Bruckner-Tuderman L, Fertala A, Uitto J, Peltonen S. Compound heterozygous desmoplakin mutations result in a phenotype with a combination of myocardial, skin, hair, and enamel abnormalities. J Invest Dermatol 130:96–78, 2010.
    IF 8.551 [abstract]
23. Haze A, Taylor AL, Haegewald S, Leiser Y, Shay B, Rosenfeld E, Gruenbaum-Cohen Y, Dafni L, Zimmermann B, Heikinheimo K, Gibson CW, Fisher LW, Young MF, Blumenfeld A, Bernimoulin JP, Deutsch D. Regeneration of bone and periodontal ligament induced by recombinant amelogenin after periodontitis. J Cell Mol Med Vol 13, No 6:1110–1124, 2009.
    IF 5.310 [abstract]
24. Mahoney MG, Sadowski S, Brennan D, Pikander P, Saukko P, Wahl J, Aho, Heikinheimo K, Bruckner-Tuderman L, Fertala A, Uitto J, Peltonen S. Compound heterozygous mutations in desmoplakin result in novel phenotypes of ectodermal dysplasia. J Invest Dermatol 129:87, 2010.
    IF 8.551 [abstract]
25. Rautava J, Jee KJ, Nagy B, Miettinen PJ, Odell EW, Soukka T, Morgan PR, Heikinheimo K. ERBB receptors in developing, dysplastic and malignant oral epithelia. Oral Oncol 44(3):227–235, 2008.
    IF 5.337 [abstract]
26. Rautava J, Luukkaa M, Heikinheimo K, Alin J, Grenman R, Happonen RP. Squamous cell carcinomas arising from different types of oral epithelia differ in their tumor and patient characteristics and survival. Oral Oncol 43(9):911–919, 2007.
    IF 5.337 [abstract]
27. Heikinheimo K, Jee KJ, Morgan PR, Nagy B, Knuutila S, Leivo I. Genetic changes in sporadic keratocystic odontogenic tumors (odontogenic keratocysts). J Dent Res 86(6):544–549, 2007.
    IF 6.116 [abstract]
28. Heikinheimo K, Mori K, Nagatsuka H, Happonen RP. Transforming growth factor beta (TGF-β) gene family members in developing and neoplastic odontogenic tissues. J Hard Tissue Biol 15(1):1–5, 2006.
    IF 0.579 [abstract]
29. Gardner DG, Heikinheimo K, Shear M, Philipsen HP, Coleman H. Ameloblastomas, in Barnes I, Eveson JW, Reichart P, Sidransky D Eds: World Health Organization Classification of Tumours. Pathology and Genetics of Head and Neck Tumours. IARC Press, Lyon 296–300, 2005.
    [summary]
30. Leivo I, Jee KJ, Heikinheimo K, Laine M, Ollila J, Nagy B, Knuutila S. Characterization of gene expression in major types of salivary gland carcinomas with epithelial differentiation. Cancer Genet Cytogenet renamed Cancer Genet 156:104–113, 2005.
    IF 2.523 [abstract]
31. Odell EW, Aldred M, Carlos R, Curran A, Heikinheimo K, Hille J, Ho HK, Kratochvil FJ, Lau SH, Murrah V, Reichart P, Sood A, Tanaka Y, Tilakaratne WM, Yih WY. Clinico-Pathological Conference 2002. Ann Acad Med Singap 33 (Suppl):53S–58S, 2004.
    IF 2.473
32. Heikinheimo K, Kokkari A, Turunen T, Aro H. Kasvutekijöiden käyttömahdollisuuksia luupuutosten ja -sairauksien hoidossa. Duodecim 120:311–318, 2004.
    [artikkeli (in Finnish)]
33. Merne M, Heikinheimo K, Saloniemi I, Syrjänen S. Effects of snuff-extract on epithelial growth and differentiation in vitro. Oral Oncol 40:6–12, 2004.
    IF 5.337 [abstract]
34. Rautava J, Soukka T, Inki P, Leimola-Virtanen R, Saloniemi I, Happonen RP, Heikinheimo K. CD44v6 in developing, dysplastic and malignant oral epithelia. Oral Oncol 39(4):373–379, 2003.
    IF 5.337 [abstract]
35. Rautava J, Soukka T, Heikinheimo K, Miettinen PJ, Happonen RP, Jaakkola P. Different mechanisms of syndecan-1 activation through a Fibroblast-Growth-Factor-inducible response element (FIRE) in mucosal and cutaneous wounds. J Dent Res 82(5):382–387, 2003.
    IF 6.116 [abstract]
36. Larsson Å, Swartz K, Heikinheimo K. A case of multiple AOT-like jawbone lesions in a young patient – a new odontogenic entity? J Oral Pathol Med 32:55–56, 2003.
    IF 4.253 [abstract]
37. Heikinheimo K, Jee KJ, Niini T, Aalto Y, Happonen RP, Leivo I, Knuutila S. Gene-expression profiling of ameloblastoma and human tooth germ by means of a cDNA microarray. J Dent Res 81(8):525–530, 2002.
    IF 6.116 [abstract]
38. Jääskeläinen K, Jee KJ, Leivo I, Saloniemi I, Knuutila S, Heikinheimo K. Cell proliferation and chromosomal changes in human ameloblastoma. Cancer Genet Cytogenet renamed Cancer Genet 136:31–37, 2002.
    IF 2.523 [abstract]
39. Ferguson CA, Tucker AS, Heikinheimo K, Nomura M, Oh P, Li E, Sharpe PT. The role of effectors of the activin signalling pathway, activin receptors IIA and IIB and Smad 2, in patterning of tooth development. Development 128(22):4605–13, 2001.
    IF 6.868 [abstract]
40. Mao Z, Shay B, Hekmati M, Fermon E, Taylor A, Dafni L, Heikinheimo K, Lustmann J, Fisher LW, Yong M, Deutsch D. The human tuftelin gene: cloning and characterization. Gene 279(2):181–196, 2001.
    IF 3.688 [abstract]
41. Heikinheimo K, Turunen T, Luostarinen V, Kuusilehto A. Maha-suolikanavan sairauksien aiheuttamat suumuutokset. Suomen Lääkärilehti (Finnish Medical Journal) 18:1999–2005, 2001.
    [artikkeli (in Finnish)]
42. Heikinheimo KA, Laine MA, Ritvos O, Voutilainen R, Hogan BLM, Leivo I. Bone morphogenetic protein-6 is a marker of serous acinar cell differentiation in normal and neoplastic human salivary gland. Cancer Res 59: 5815–5821, 1999. Erratum in: Cancer Res 60(13):3668, 2000. Heikinheimo AK [corrected to Heikinheimo KA].
    IF 12.701 [abstract]
43. Heikinheimo K, Turunen T, Kuusilehto A. Keliakian aiheuttamat suumuutokset. Suomen Hammaslääkärilehti (Finnish Dental Journal) 21:1110–1113, 1999.
    [abstrakti (in Finnish)]
44. Pohjola J, Kuusilehto A, Heikinheimo K. Suun limakalvon valkeat muutokset. Suomen Lääkärilehti (Finnish Medical Journal) 33:4089–4095, 1999.
    
45. Jaatinen R, Laitinen MP, Vuojolainen K, Aaltonen J, Louhio H, Butzow R, Heikinheimo K, Lehtonen E, Ritvos O. Localization of growth/differentiation factor-9 (GDF-9) mRNA and protein in human and rat ovaries and cDNA cloning of rat GDF-9 and its novel homolog GDF-9B. Mol Cell Endocrinol 56:189–193, 1999.
    IF 4.102 [abstract]
46. Salo T, Kainulainen T, Parikka M, Heikinheimo K. Expression of laminin-5 in ameloblastomas and human fetal teeth. J Oral Pathol Med 28:337–342, 1999.
    IF 4.253 [abstract]
47. Heikinheimo K, Kuusilehto A. Crohnin taudin aiheuttamat muutokset suun limakalvolla. Suomen Hammaslääkärilehti (Finnish Dental Journal) 21:1154–1156, 1998.
    
48. Heikinheimo K, Bègue-Kirn C, Ritvos O, Tuuri T, Ruch JV. Activin and bone morphogenetic protein (BMP) signaling during tooth development. Eur J Oral Sci 106:167–173, 1998.
    IF 2.612 [abstract]
49. Kuusilehto A, Lehtinen R, Happonen RP, Heikinheimo K, Lehtimäki K, Jansén CT. An open clinical trial of a new mouth-PUVA variant in the treatment of oral lichenoid lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 84:502–505, 1997.
    IF 2.589 [abstract]
50. Heikinheimo K, Bègue-Kirn C, Ritvos O, Tuuri T, Ruch JV. The activin-binding protein follistatin is expressed in developing murine molar and induces odontoblast-like cell differentiation in vitro. J Dent Res 76:1625–1636, 1997.
    IF 6.116 [abstract]
51. Luomanen M, Tiitta O, Heikinheimo K, Leimola-Virtanen R, Heinaro I, Happonen RP. Effect of snuff and smoking on tenascin expression of oral mucosa. J Oral Pathol Med 26:334–338, 1997.
    IF 4.253 [abstract]
52. Luomanen M, Tiitta O, Heikinheimo K, Heinaro I, Happonen RP. Effect of snuff on cytokeratin expression in oral vestibular sulcus epithelium. J Oral Pathol Med 26:110–106, 1997.
    IF 4.253 [abstract]
53. Heikinheimo K and Salo T. Expression of basement membrane type IV collagen and type IV collagenases (MMP-2 and MMP-9) in human fetal teeth. J Dent Res 74:1226–1234, 1995.
    IF 6.116 [abstract]
54. Heikinheimo K. Stage-specific expression of decaplentaplegic-Vg-related genes 2, 4 and 6 (bone morphogenetic proteins 2, 4 and 6) during human tooth morphogenesis. J Dent Res 73:590–597, 1994.
    IF 6.116 [abstract]
55. Heikinheimo K. Cell growth and differentiation of developing and neoplastic odontogenic tissues. Thesis, University of Turku, 1993.
    
56. Heikinheimo K, Voutilainen R, Happonen RP and Miettinen PJ. EGF-receptor and its ligands, EGF and TGF-α, in developing and neoplastic odontogenic tissues. Int J Dev Biol 37:387–396, 1993.
    IF 2.204 [abstract]
57. Erämaa M, Heikinheimo K, Tuuri T, Hildén K and Ritvos O. Inhibin/activin subunit mRNA expression in human granulosa-luteal cells. Mol Cell Endocrinol 92:R15–R20, 1993.
    IF 4.102 [abstract]
58. Heikinheimo K, Happonen RP, Miettinen PJ and Ritvos O. Transforming growth factor beta 2 in epithelial differentiation of developing teeth and odontogenic tumors. J Clin Invest 91:1019–1027, 1993.
    IF 8.315 [abstract]
59. Erämaa M, Heikinheimo K, Voutilainen R. Developmental and cyclic adenosine 3',5'monophosphate-dependent regulation of inhibin subunit messenger ribonucleic acids in human fetal testes. J Clin Endocr Metab 75:806–811, 1992.
    IF 5.958 [abstract]
60. Miettinen PJ and Heikinheimo K. Transforming growth factor-alpha (TGF-α) and insulin gene expression in human fetal pancreas. Development 114:833–840, 1992.
    IF 6.868 [abstract]
61. Heikinheimo K, Sandberg M, Happonen RP, Virtanen I and Bosch FX. Cytoskeletal gene expression in normal and neoplastic odontogenic epithelia. Lab Invest 65, 688–701, 1991.
    IF 5.662 [abstract]
62. Heikinheimo K, Morgan P, Happonen RP, Stenman G and Virtanen I. Distribution of extracellular matrix proteins in human odontogenic tumors and developing teeth. Virchows Arch 61:101–109, 1991.
    IF 4.064 [abstract]
63. Heikinheimo K and Happonen RP. In situ hybridization using single stranded antisense RNA probes in research of oral pathology. Proc Finn Dent Soc 87:245-257, 1991.
    [abstract]
64. Heikinheimo K, Persson S, Morgan PR, Kindblom L-G and Virtanen I. Expression of different cytokeratin subclasses in human chordoma. J Pathol 164:145–150, 1991.
    IF 7.996 [abstract]
65. Sandros J, Heikinheimo K, Happonen RP and Stenman G. Expression of the P21RAS in odontogenic tumors. APMIS 99:15–20, 1991.
    IF 3.205 [abstract]
66. Söderholm A-L, Lindqvist C, Heikinheimo K, Forssell K and Happonen RP. Non-Hodgkin lymphomas presenting through oral symptoms. Int J Oral Max Surg 19:131–134, 1990.
    IF 2.789 [abstract]
67. Heikinheimo K, Hormia M, Stenman G, Virtanen I and Happonen RP. Patterns of expression of intermediate filaments in ameloblastoma and human fetal tooth germ. J Oral Pathol Med 18:264–273, 1989.
    IF 4.253 [abstract]
68. Happonen RP and Heikinheimo K. Introduction to immunocytochemistry. Proc Finn Dent Soc 85:61-67, 1989.
    [abstract]
69. Virtanen I, Heikinheimo K, Hormia M, Kivelä T, Laitinen L and Thornell L-E. Expression of intermediate filaments (IF) in tissues and cultured cells. Int J Dev Biol 33:55–61, 1989.
    IF 2.204 [abstract]
70. Heikinheimo K, Happonen RP, Forssell K, Kuusilehto A and Virtanen I. A botryoid odontogenic cyst with multiple recurrences. Int J Oral Max Surg 18:10–13, 1989.
    IF 2.789 [abstract]
71. Hormia M, Heikinheimo K, Happonen RP, Luomanen M, Ylipaavalniemi P and Virtanen I. Cytokeratins and the oral cavity - new methods for pathological diagnosis. Proc Finn Dent Soc 84:3-11, 1988.
    [link]
72. Happonen RP, Heikinheimo K, Alitalo K, Ekfors TO and Calonius PEB. Chondrosarcoma of the jaws. Review of the literature and report of two cases. Proc Finn Dent Soc 81:135–141, 1985.
    [link]

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